Publications

* Equal contribution
# Co-corresponding author

Transdifferentiation Occurs Without Resetting Development-specific DNA Methylation, a Key Determinant of Full-Function Cell Identity

Radwan A*, Eccleston J*, Sabag O, Marcus H, Sussman J, Ouro A, Rahamim M, Azagury M, Azria B, Stanger B Z#, Cedar H#, Buganim Y#.

Proc Natl Acad Sci U S A. (2024)

Unlocking Trophectoderm Mysteries: In Vivo and In Vitro Perspectives on Human and Mouse Trophoblast Fate Induction

Azagury M, Buganim Y.

Developmental Cell (2024)

Differentiation Shifts from a Reversible to an Irreversible Heterochromatin State at the DM1 Locus

Handal T*, Juster S*, Abu Diab M*, Yanovsky-Dagan S, Zahdeh F, Aviel U, Sarel-Gallily R, Michael S, Bnaya E, Sebban S, Buganim Y, Drier Y, Mouly V, Kubicek S, Van den Broek W J A A, Wansink D G, Epsztejn-Litman S, Eiges R.

Nature Communications (2024)

Complex Haploinsufficiency in Pluripotent Cells Yields Somatic Cells with DNA Methylation Abnormalities and Pluripotency Induction Defects

Lasry R*, Maoz N*, Cheng A. W, Yom Tov N, Kulenkampff E, Azagury A, Yang H, Ople O, Markoulaki S, Faddah A. D, Makedonski K, Orzech D, Sabbag O, Jaenisch R, Buganim Y.

Stem Cell Reports (2023)

Human Trophoblast Stem Cell-state Acquisition from Pluripotent Stem Cells and Somatic Cells

Naama M, Buganim Y.

Curr Opin Genet Dev. (2023)

Invited article for a series on 'Early Embryonic Development Models'.

Pluripotency-independent Induction of Trophoblast Stem Cells from Human Fibroblasts

Naama M*, Rahamim M*, Zayat V, Sebban S, Radwan A, Orzech D, Lasry R, Ifrah A, Jaber M, Sabag O, Yassen H, Khatib A, Epsztejn-Litman S, Novoselsky-Persky M, Makedonski K, Deri N, Goldman-Wohl D, Cedar H, Yagel S, Eiges R, Buganim Y.

Nature Communications (2023)

NAD Depletion Mediates Cytotoxicity in Human Neurons with Autophagy Deficiency

Sun C, Seranova E, Cohen MA, Chipara M, Roberts J, Astuti D, Palhegyi AM, Acharjee A, Sedlackova L, Kataura T, Otten EG, Panda PK, Lara-Reyna S, Korsgen ME, Kauffman KJ, Huerta-Uribe A, Zatyka M, Silva LFSE , Torresi J, Zhang S, Hughes GW, Ward C, Kuechler ER, Cartwright D, Trushin S, Trushina E, Sahay G, Buganim Y, Lavery GG, Gsponer J, Anderson D, Frickel E, Rosenstock TR, Barrett T, Maddocks ODK , Tennant DA, Wang H, Jaenisch R, Korolchuk VI#, Sarkar S#.

Cell Reports (2023)

Comparative Parallel Multi-Omics Analysis of Cell Undergoing Reprogramming to Pluripotent and Trophectoderm States

Jaber M*, Radwan A*, Loyfer N*, Abdeen M, Sebban S, Khatib A, Azagory M, Kolb T, Zapatka M, Makedonski K, Ernst E, Kaplan T#, Buganim Y#.

Nature Communications (2022)

Esrrb is a Cell-cycle-dependent Associated Factor Balancing Pluripotency and XEN Differentiation

Herchcovici Levy S, Feldman Cohen S, Arnon L, Lahav S, Awawdy M, Alajem A, Bavli D, Sun X, Buganim Y, Ram O.

Stem Cell Reports (2022)

In silico Docking Analysis for Blocking JUNO‐IZUMO1 Interaction Identifies Two Small Molecules that Block in vitro Fertilization

Stepanenko N*, Wolk O*, Bianchi E, Wright G.J, Schachter-Safrai N, Makedonski K, Ouro A, Ben-Meir A, Buganim Y, Goldblum A.

Front Cell Dev Biol. (2022)

Targeting Neurons in the Tumor Microenvironment with Bupivacaine Nanoparticles Reduces Breast Cancer Progression and Metastases

Kaduri M, Sela S, Kagan S, Poley M, Abumanhal-Masarweh H, Mora-Raimundo P, Ouro A, Dahan N, Hershkovitz D, Shklover J, Shainsky-Roitman J, Buganim Y, Schroeder A.

Science Advances (2021)

Apoptotic Cells Represent a Dynamic Stem Cell Niche Governing Proliferation and Tissue regeneration

Ankawa R, Goldberger N, Yosefzon Y, Koren E, Yusupova M, Rosner D, Feldman A, Baror-Sebban S, Buganim Y, Simon D, Tessier-Lavigne M, Fuchs Y.

Developmental Cell (2021)

A Versatile System to Introduce Clusters of Genomic Double-strand Breaks in Large Cell Populations

Kolb T, Khalid U, Simović M, Ratnaparkhe M, Wong J, Jauch A, Schmezer P, Rode A, Sebban S, Haag D, Hergt M, Devens F, Buganim Y, Zapatka M, Lichter P, Ernst A.

Genes Chromosomes Cancer (2020)

Human Induced Pluripotent Stem Cell Models of Neurodegenerative Disorders for Studying the Biomedical Implications of Autophagy

Seranova E, Palhegyi AM, Verma S, Dimova S, Lasry R, Naama M, Sun C, Barrett T, Rosenstock TR, Kumar D, Cohen MA, Buganim Y, Sarkar S.

J Mol Biol. (2020)

Triangular Correlation (TrC) between Cancer Aggressiveness, Cell Uptake Capability, and Cell Deformability

Brill-Karniely Y*, Dror D*, Duanis-Assaf T, Goldstein Y, Schwob O, Millo T, Orehov N, Stern T, Jaber M, Loyfer N, Vosk-Artzi M, Benyamini H, Bielenberg D, Kaplan T, Buganim Y, Reches M, Benny O.

Science Advances (2020)

Direct Induction of the Three Pre-Implantation Blastocyst Cell Types from Fibroblasts

Benchetrit H*, Jaber M*, Zayat V*, Sebban S, Pushett A, Makedonski K, Zakheim Z, Radwan A, Maoz N, Lasry R, Renous N, Inbar M, Ram O, Kaplan T, Buganim Y.

Cell Stem Cell (2019)

Fine-Tuning Mybl2 Is Required for Proper Mesenchymal-to-Epithelial Transition during Somatic Reprogramming

Ward C, Volpe G, Cauchy P, Ptasinska A, Almaghrabi R, Blakemore D, Nafria M, Kestner D, Frampton J, Murphy G, Buganim Y, Kaji K, García P.

Cell Reports (2018)

Germline DNA Replication Timing Shapes Mammalian Genome Composition

Yehuda Y, Blumenfeld B, Mayorek N, Makedonski K, Vardi O, Cohen-Daniel L, Mansour Y, Baror-Sebban S, Masika H, Farago M, Berger M, Carmi S, Buganim Y, Koren A, Simon I.

Nucleic Acids Research (2018)

Programming Asynchronous Replication in Stem Cells

Masika H, Farago M, Hecht M, Condiotti R, Makedonski K, Buganim Y, Burstyn-Cohen T, Bergman Y, Cedar H.

Nat Struct Mol Biol. (2017)

Acquisition of the Pluripotent and Trophectoderm States in the Embryo and during Somatic Nuclear Reprogramming

Jaber M, Sebban S, Buganim Y.

Curr Opin Genet Dev. (2017)

Invited article for a series on 'Cell Reprogramming'.

Moving Towards Totipotency without a Single miR-acle

Maoz N, Buganim Y.

Cell Research (2017)

Back to Basics: Refined Nuclear Reprogramming Techniques Yield Higher-Quality Stem Cells

Buganim Y.

Science (2016)

Human Neural Crest Cells Contribute to Coat Pigmentation in Interspecies Chimeras after In Utero Injection into Mouse Embryos

Cohen MA, Wert KJ, Goldmann J, Markoulaki S, Buganim Y, Fu D, Jaenisch R.

Proc Natl Acad Sci U S A. (2016)

Nuclear Reprogramming by Defined Factors: Quantity vs Quality

Sebban S, Buganim Y.

Trends in Cell Biology (2016)

Extensive Nuclear Reprogramming Underlies Lineage Conversion into Functional Trophoblast Stem-like Cells

Benchetrit H, Herman S, van Wietmarschen N, Wu T, Makedonski K, Maoz N, Yom Tov N, Stave D, Lasry R, Zayat V, Xiao A, Lansdorp P.M, Sebban S, Buganim Y.

Cell Stem Cell (2015)

Tex10: A New Player in the Core Pluripotency Circutry

Buganim Y.

Cell Stem Cell (2015)

The Developmental Potential of iPSCs is Greatly Influenced by Reprogramming Factor Selection

Buganim Y*#, Markoulaki S*, Wietmarschen VN, Hoke H, Wu T, Ganz K, Akhtar-Zaidi B, He Y, Abraham B.J, Porubsky D, Kulenkampff E, Faddah D.A, Shi L, Gao Q, Sarkar S, Cohen M, Goldmann J, Nery J.R, Schultz M.J, Ecker J.R, Xiao A, Young R.A, Lansdorp P.M, Jaenisch R#.

Cell Stem Cell (2014)

Impaired Autophagy in the Lipid-storage Disorder Niemann-Pick Type C1 Disease

Sarkar S, Carroll B, Buganim Y, Maetzel D, Ng AH, Cassady JP, Cohen MA, Chakraborty S, Wang H, Spooner E, Ploegh H, Gsponer J, Korolchuk VI, Jaenisch R.

Cell Reports (2013)