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* Equal contribution
# Co-corresponding author

Fibroblasts-derived from Pluripotent Cells Harboring a Single Allele Knockout in Two Pluripotency Genes Exhibit DNA Methylation Abnormalities and pluripotency induction Defects

Lasry R*, Maoz N*, Cheng A. W, Yom Tov N, Kulenkampff E, Azagury A, Yang H, Ople O, Markoulaki S, Faddah A. D, Makedonski K, Sabbag O,  Jaenisch R, Buganim Y.


Pluripotency-independent Induction of Trophoblast Stem Cells from Human Fibroblasts

Naama N, Radwan A, Zayat V, Sebban S, Rahamim M, Lasry R, Jaber M, Sabag O, Yassen H, Orzech D, Khatib A, Epsztejn-Litman S, Novoselsky-Persky M, Makedonski K, Deri N, Goldman-Wohl D, Cedar H, Yagel S, Eiges R, Buganim Y.


Comparative Parallel Multi-Omics Analysis of Cell Undergoing Reprogramming to Pluripotent and Trophectoderm States

Jaber M*, Radwan A*, Loyfer N*, Abdeen M, Sebban S, Khatib A, Azagory M, Kolb T, Zapatka M, Makedonski K, Ernst E, Kaplan T#, Buganim Y#.

Nat Commun. (2022)

Esrrb is a Cell-cycle-dependent Associated Factor Balancing Pluripotency and XEN Differentiation

Herchcovici Levy S, Feldman Cohen S, Arnon L, Lahav S, Awawdy M, Alajem A, Bavli D, Sun X, Buganim Y, Ram O.

Stem Cell Reports. (2022)

A Versatile System to Introduce Clusters of Genomic Double-strand Breaks in Large Cell Populations

Kolb T, Khalid U, Simović M, Ratnaparkhe M, Wong J, Jauch A, Schmezer P, Rode A, Sebban S, Haag D, Hergt M, Devens F, Buganim Y, Zapatka M, Lichter P, Ernst A.

Genes Chromosomes Cancer. (2020)

Human Induced Pluripotent Stem Cell Models of Neurodegenerative Disorders for Studying the Biomedical Implications of Autophagy

Seranova E, Palhegyi AM, Verma S, Dimova S, Lasry R, Naama M, Sun C, Barrett T, Rosenstock TR, Kumar D, Cohen MA, Buganim Y, Sarkar S.

J Mol Biol. (2020)

Triangular Correlation (TrC) between Cancer Aggressiveness, Cell Uptake Capability, and Cell Deformability

Brill-Karniely Y*, Dror D*, Duanis-Assaf T, Goldstein Y, Schwob O, Millo T, Orehov N, Stern T, Jaber M, Loyfer N, Vosk-Artzi M, Benyamini H, Bielenberg D, Kaplan T, Buganim Y, Reches M, Benny O.

Sci Adv. (2020)

Direct Induction of the Three Pre-Implantation Blastocyst Cell Types from Fibroblasts

Benchetrit H*, Jaber M*, Zayat V*, Sebban S, Pushett A, Makedonski K, Zakheim Z, Radwan A, Maoz N, Rachel Lasry, Renous N, Inbar M, Ram O, Kaplan T, Buganim Y.

Cell Stem Cell. (2019)

Fine-Tuning Mybl2 Is Required for Proper Mesenchymal-to-Epithelial Transition during Somatic Reprogramming

Ward C, Volpe G, Cauchy P, Ptasinska A, Almaghrabi R, Blakemore D, Nafria M, Kestner D, Frampton J, Murphy G, Buganim Y, Kaji K, García P.

Cell Rep. (2018)

Germline DNA Replication Timing Shapes Mammalian Genome Composition

Yehuda Y, Blumenfeld B, Mayorek N, Makedonski K, Vardi O, Cohen-Daniel L, Mansour Y, Baror-Sebban S, Masika H, Farago M, Berger M, Carmi S, Buganim Y, Koren A, Simon I.

Nucleic Acids Res. (2018)

Programming Asynchronous Replication in Stem Cells

Masika H, Farago M, Hecht M, Condiotti R, Makedonski K, Buganim Y, Burstyn-Cohen T, Bergman Y, Cedar H.

Nat Struct Mol Biol. (2017)

Moving Towards Totipotency without a Single miR-acle 

Maoz N, Buganim Y.

Cell Res. (2017)

Human Neural Crest Cells Contribute to Coat Pigmentation in Interspecies Chimeras after In Utero Injection into Mouse Embryos

Cohen MA, Wert KJ, Goldmann J, Markoulaki S, Buganim Y, Fu D, Jaenisch R.

Proc Natl Acad Sci U S A. (2016)

Nuclear Reprogramming by Defined Factors: Quantity vs Quality

Sebban S, Buganim Y.

Trends in Cell Biol. (2016)

Extensive Nuclear Reprogramming Underlies Lineage Conversion into Functional Trophoblast Stem-like Cells

Benchetrit H, Herman S, van Wietmarschen N, Wu T, Makedonski K, Maoz N, Yom Tov N, Stave D, Lasry R, Zayat V, Xiao A, Lansdorp P.M, Sebban S, Buganim Y.

Cell Stem Cell. (2015)

The Developmental Potential of iPSCs is Greatly Influenced by Reprogramming Factor Selection

Buganim Y*#, Markoulaki S*, Wietmarschen VN, Hoke H, Wu T, Ganz K, Akhtar-Zaidi B, He Y, Abraham B.J, Porubsky D, Kulenkampff E, Faddah D.A, Shi L, Gao Q, Sarkar S, Cohen M, Goldmann J, Nery J.R, Schultz M.J, Ecker J.R, Xiao A, Young R.A, Lansdorp P.M, Jaenisch R#.

Cell Stem Cell. (2014)

Impaired Autophagy in the Lipid-storage Disorder Niemann-Pick Type C1 Disease

Sarkar S, Carroll B, Buganim Y, Maetzel D, Ng AH, Cassady JP, Cohen MA, Chakraborty S, Wang H, Spooner E, Ploegh H, Gsponer J, Korolchuk VI, Jaenisch R.

Cell Rep. (2013)

Efficiency of siRNA Delivery by Lipid Nanoparticles is Limited by Endocytic Recycling

Sahay G, Querbes W, Alabi C, Eltoukhy A, Sarkar S, Zurenko C, Karagiannis E, Love K, Chen D, Zoncu R, Buganim Y, Schroeder A, Langer R, Anderson DG.

Nat Biotechnol. (2013)

Mechanisms and  Models of Somatic Cell Reprogramming

Buganim Y, Faddah DA, Jaenisch R.

Nat Rev Genet. (2013)

Single-cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase

Buganim Y*, Faddah DA*, Cheng AW, Itskovich E, Markoulaki S, Ganz K, Klemm SL, van Oudenaarden A, Jaenisch R.

Cell. (2012)

Direct Reprogramming of Fibroblasts into Embryonic Sertoli-like Cells by Defined Factors

Buganim Y#, Itskovich E, Hu YC, Cheng AW, Ganz K, Sarkar S, Fu D, Welstead GG, Page DC, Jaenisch R#.

Cell Stem Cell. (2012)

Reprogramming Factor Stoichiometry Influences the Epigenetic State and Biological Properties of Induced Pluripotent Stem Cells

Carey BW, Markoulaki S, Hanna JH, Faddah DA, Buganim Y, Kim J, Ganz K, Steine EJ, Cassady JP, Creyghton MP, Welstead GG, Gao Q, Jaenisch R.

Cell Stem Cell. (2011)

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